FBXO6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NPTN
Gene Ontology Biological Process
- homophilic cell adhesion via plasma membrane adhesion molecules [ISS]
- long-term synaptic potentiation [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of fibroblast growth factor receptor signaling pathway [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TGF? attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.
FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the development of osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on the pathogenesis of OA remains undefined.The ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FBXO6 NPTN | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 729080 |
Curated By
- BioGRID