BAIT
FBXO6
FBG2, FBS2, FBX6, Fbx6b, RP3-330O12.3
F-box protein 6
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SERPINE2
GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
GO Process (8)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of blood coagulation [IC, IDA]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of plasminogen activation [IMP]
- negative regulation of platelet aggregation [ISS]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [IDA]
- positive regulation of astrocyte differentiation [IDA]
- regulation of cell migration [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TGF? attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.
FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the development of osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on the pathogenesis of OA remains undefined.The ... [more]
Ann Rheum Dis Dec. 01, 2019; 79(8);1111-1120 [Pubmed: 32409323]
Throughput
- High Throughput
Curated By
- BioGRID