RFX4
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA, IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA, IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IBA]
RFX3
Gene Ontology Biological Process
- cell maturation [ISS]
- cilium assembly [IBA, ISS]
- cilium-dependent cell motility [ISS]
- endocrine pancreas development [ISS]
- epithelial cilium movement involved in determination of left/right asymmetry [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of type B pancreatic cell development [ISS]
- regulation of insulin secretion [ISS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [ISS]
- transcription from RNA polymerase II promoter [TAS]
- type B pancreatic cell differentiation [IBA]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.
Regulatory factor X (RFX) members are evolutionarily conserved transcription factors that share a highly conserved winged helix DNA-binding domain. Human RFX4 has been isolated from breast cancer as a partial cDNA encoding a short RFX-type DNA-binding domain fused to the estrogen receptor, but the entire structure of RFX4 has been unknown. Here, we report the molecular cloning and characterization of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID