BAIT
SIRT7
SIR2L7
sirtuin 7
GO Process (5)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
WASF2
IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2
WAS protein family, member 2
GO Process (5)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An NAD+-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39.
Ubiquitin specific protease 39 (USP39), an ortholog of Sad1p in yeast, is essential for spliceosome assembly during pre-mRNA splicing in human. Although it is known that USP39 is upregulated and plays an oncogenic role in hepatocellular carcinoma (HCC), the underlying mechanism remains unknown. The results of this study demonstrated that USP39 can be acetylated by the histone acetyltransferase MYST1, which ... [more]
iScience Aug. 21, 2020; 23(8);101351 [Pubmed: 32711345]
Throughput
- High Throughput
Curated By
- BioGRID