RHOH
Gene Ontology Biological Process
- T cell differentiation [NAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of catalytic activity [NAS]
- negative regulation of phosphorylation [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- regulation of transcription, DNA-templated [NAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
ARHGDIB
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- cellular component movement [TAS]
- immune response [TAS]
- multicellular organismal development [TAS]
- negative regulation of cell adhesion [TAS]
- regulation of catalytic activity [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization, affecting diverse cellular responses, including adhesion, cytokinesis, and motility. Another major function of the Rho GTPases is their role in regulating transcriptional factors and nuclear signaling. RhoH is encoded by a hematopoiesis-specific Rho-related gene recently identified in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID