CD36
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- cGMP-mediated signaling [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to bacterial lipopeptide [IMP]
- cellular response to hydroperoxide [IMP]
- cellular response to lipopolysaccharide [IMP]
- cellular response to lipoteichoic acid [IDA, IMP]
- cholesterol transport [IMP]
- defense response to Gram-positive bacterium [IMP]
- fatty acid metabolic process [ISO]
- fatty acid oxidation [ISO]
- fatty acid transport [ISO]
- lipid storage [IMP, ISO]
- lipoprotein transport [IMP, ISO]
- long-chain fatty acid import [ISO]
- long-chain fatty acid metabolic process [ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle clearance [IMP, ISO]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of angiogenesis [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of growth of symbiont in host [IMP]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of transcription factor import into nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nitric oxide mediated signal transduction [ISO]
- pattern recognition receptor signaling pathway [IMP]
- phagocytosis, recognition [IDA]
- plasma lipoprotein particle clearance [IMP]
- plasma membrane long-chain fatty acid transport [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of blood microparticle formation [IMP]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of cholesterol storage [IMP]
- positive regulation of cytokine secretion [ISO]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of macrophage derived foam cell differentiation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phagocytosis, engulfment [IDA, IMP]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of removal of superoxide radicals [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IC]
- response to mechanical stimulus [ISO]
- signal transduction [ISO]
- triglyceride metabolic process [ISO]
Gene Ontology Molecular Function- high-density lipoprotein particle binding [IDA]
- lipid binding [ISO, ISS]
- lipoprotein particle binding [ISO]
- lipoteichoic acid receptor activity [IMP]
- low-density lipoprotein particle binding [IMP, ISO]
- low-density lipoprotein receptor activity [IMP, ISO]
- oleic acid binding [ISO]
- protein binding [IPI]
- thrombospondin receptor activity [ISO]
- transforming growth factor beta binding [ISO]
- high-density lipoprotein particle binding [IDA]
- lipid binding [ISO, ISS]
- lipoprotein particle binding [ISO]
- lipoteichoic acid receptor activity [IMP]
- low-density lipoprotein particle binding [IMP, ISO]
- low-density lipoprotein receptor activity [IMP, ISO]
- oleic acid binding [ISO]
- protein binding [IPI]
- thrombospondin receptor activity [ISO]
- transforming growth factor beta binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [ISO]
- caveola [ISO]
- cell surface [ISO, ISS]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- intracellular [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [IDA]
- mitochondrion [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [ISO]
UCHL1
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- axon target recognition [IMP]
- axon transport of mitochondrion [IMP]
- axonogenesis [IMP]
- cell proliferation [IMP]
- eating behavior [IGI]
- muscle fiber development [IGI]
- negative regulation of MAP kinase activity [ISO]
- neuromuscular process [IMP]
- protein deubiquitination [ISO]
- response to ischemia [IMP]
- sensory perception of pain [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Atherosclerosis-associated cardiovascular diseases are main causes leading to high mortality worldwide. Macrophage-derived foam cell formation via uptaking modified lipoproteins is the initial and core step in the process of atherosclerosis. Meanwhile, scavenger receptor is indispensable for the formation of foam cells. UCHL1, a deubiquitinase, has been widely studied in multiple cancers. UCHL1 could be an oncogene or a tumor suppressor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UCHL1 CD36 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID