BAIT
CD274
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
CD274 molecule
GO Process (12)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- T cell costimulation [IDA, TAS]
- cell surface receptor signaling pathway [IDA]
- immune response [IDA]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-10 production [IMP]
- negative regulation of tumor necrosis factor superfamily cytokine production [IMP]
- positive regulation of T cell proliferation [TAS]
- positive regulation of interleukin-10 secretion [IDA]
- regulation of T cell apoptotic process [IMP]
- regulation of activated T cell proliferation [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNG12
RP5-975D15.2
guanine nucleotide binding protein (G protein), gamma 12
GO Process (5)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.
Expression of programmed cell death ligand (PD-L1) is associated with poor prognosis in breast cancer. Understanding the regulation of PD-L1 expression in breast cancer could provide a new strategy for breast cancer treatment. Here, we demonstrate that moesin (MSN) phosphorylation by Rho-associated protein kinase (ROCK) stabilizes PD-L1 protein levels. Our results indicate that phosphorylated MSN may compete with the E3 ... [more]
Mol Oncol Dec. 01, 2019; 14(11);2701-2712 [Pubmed: 32941674]
Throughput
- High Throughput
Curated By
- BioGRID