BAIT
CD274
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
CD274 molecule
GO Process (12)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- T cell costimulation [IDA, TAS]
- cell surface receptor signaling pathway [IDA]
- immune response [IDA]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-10 production [IMP]
- negative regulation of tumor necrosis factor superfamily cytokine production [IMP]
- positive regulation of T cell proliferation [TAS]
- positive regulation of interleukin-10 secretion [IDA]
- regulation of T cell apoptotic process [IMP]
- regulation of activated T cell proliferation [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PSMB6
DELTA, LMPY, Y
proteasome (prosome, macropain) subunit, beta type, 6
GO Process (21)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.
Expression of programmed cell death ligand (PD-L1) is associated with poor prognosis in breast cancer. Understanding the regulation of PD-L1 expression in breast cancer could provide a new strategy for breast cancer treatment. Here, we demonstrate that moesin (MSN) phosphorylation by Rho-associated protein kinase (ROCK) stabilizes PD-L1 protein levels. Our results indicate that phosphorylated MSN may compete with the E3 ... [more]
Mol Oncol Dec. 01, 2019; 14(11);2701-2712 [Pubmed: 32941674]
Throughput
- High Throughput
Curated By
- BioGRID