EGR2
Gene Ontology Biological Process
- Schwann cell differentiation [IMP]
- brain segmentation [IMP]
- cellular response to cAMP [IBA]
- cellular response to gonadotropin stimulus [IBA]
- cellular response to organic substance [IDA]
- facial nerve structural organization [IGI]
- fat cell differentiation [IMP]
- motor neuron axon guidance [IGI]
- myelination [IMP]
- negative regulation of apoptotic process [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein export from nucleus [IDA]
- regulation of neuronal synaptic plasticity [IBA]
- regulation of ossification [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to insulin [ISO]
- rhombomere 3 development [IGI]
- rhombomere 3 formation [IMP]
- rhombomere 5 formation [IMP]
- rhythmic behavior [IDA, IMP]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
RNF20
Gene Ontology Biological Process
- histone H2B ubiquitination [ISO]
- histone monoubiquitination [ISO]
- histone ubiquitination [IMP]
- negative regulation of cell migration [ISO]
- positive regulation of histone methylation [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- protein polyubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.
Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann cell development and myelination chromatin is dramatically modified. However, impact and functional relevance of these modifications are poorly understood. Here, we analyzed histone H2B monoubiquitination ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF20 EGR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID