BAIT
TRIM37
MUL, POB1, TEF3
tripartite motif containing 37
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- aggresome assembly [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of centriole replication [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
ZNF281
ZBP-99, ZNP-99
zinc finger protein 281
GO Process (6)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- embryonic body morphogenesis [ISS]
- negative regulation of gene expression [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- stem cell differentiation [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [ISS]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [ISS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Genomic instability is a hallmark of cancer, and has a central role in the initiation and development of breast cancer1,2. The success of poly-ADP ribose polymerase inhibitors in the treatment of breast cancers that are deficient in homologous recombination exemplifies the utility of synthetically lethal genetic interactions in the treatment of breast cancers that are driven by genomic instability3. Given ... [more]
Nature Dec. 01, 2019; 585(7825);447-452 [Pubmed: 32908313]
Throughput
- High Throughput
Curated By
- BioGRID