An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

Yeow ZY, Lambrus BG, Marlow R, Zhan KH, Durin MA, Evans LT, Scott PM, Phan T, Park E, Ruiz LA, Moralli D, Knight EG, Badder LM, Novo D, Haider S, Green CM, Tutt ANJ, Lord CJ, Chapman JR, Holland AJ

Genomic instability is a hallmark of cancer, and has a central role in the initiation and development of breast cancer1,2. The success of poly-ADP ribose polymerase inhibitors in the treatment of breast cancers that are deficient in homologous recombination exemplifies the utility of synthetically lethal genetic interactions in the treatment of breast cancers that are driven by genomic instability3. Given ... [more]

Nature Dec. 01, 2019; 585(7825);447-452 [Pubmed: 32908313]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

TRIM37

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein homodimerization activity [IDA]tumor necrosis factor receptor binding [IPI]ubiquitin protein ligase binding [IPI]ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

ARHGEF18