BAIT
TRIM37
MUL, POB1, TEF3
tripartite motif containing 37
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- aggresome assembly [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of centriole replication [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
CYR61
CCN1, GIG1, IGFBP10
cysteine-rich, angiogenic inducer, 61
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- cell adhesion [IBA]
- cell proliferation [TAS]
- cell-cell signaling [IBA]
- negative regulation of cell death [IBA]
- positive regulation of BMP signaling pathway [IGI]
- positive regulation of cell migration [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ERK1 and ERK2 cascade [IDA]
- wound healing, spreading of cells [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Genomic instability is a hallmark of cancer, and has a central role in the initiation and development of breast cancer1,2. The success of poly-ADP ribose polymerase inhibitors in the treatment of breast cancers that are deficient in homologous recombination exemplifies the utility of synthetically lethal genetic interactions in the treatment of breast cancers that are driven by genomic instability3. Given ... [more]
Nature Dec. 01, 2019; 585(7825);447-452 [Pubmed: 32908313]
Throughput
- High Throughput
Curated By
- BioGRID