BAIT
ATG5
APG5, APG5-LIKE, APG5L, ASP, hAPG5
autophagy related 5
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IBA, ISS]
- autophagy [ISS]
- cellular response to nitrogen starvation [IBA]
- innate immune response [TAS]
- mitochondrion degradation [IBA]
- negative regulation of type I interferon production [TAS]
- nucleophagy [IBA]
- post-translational protein modification [ISS]
- regulation of cilium assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
S100A9
60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
S100 calcium binding protein A9
GO Process (18)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- autophagy [IDA]
- cell-cell signaling [TAS]
- chemokine production [TAS]
- cytokine production [TAS]
- defense response to bacterium [TAS]
- defense response to fungus [TAS]
- inflammatory response [TAS]
- leukocyte migration involved in inflammatory response [IDA]
- neutrophil aggregation [IDA]
- neutrophil chemotaxis [IDA]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of inflammatory response [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of cytoskeleton organization [TAS]
- sequestering of zinc ion [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ISG15 Connects Autophagy and IFN-?-Dependent Control of Toxoplasma gondii Infection in Human Cells.
The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-?) is the major cytokine involved in activating cell-autonomous immune responses to inhibit parasite growth within this intracellular niche. In HeLa cells, IFN-? treatment leads to ubiquitination of susceptible parasite strains, recruitment ... [more]
mBio Dec. 06, 2019; 11(5); [Pubmed: 33024031]
Throughput
- Low Throughput
Curated By
- BioGRID