BAIT
ATG5
APG5, APG5-LIKE, APG5L, ASP, hAPG5
autophagy related 5
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IBA, ISS]
- autophagy [ISS]
- cellular response to nitrogen starvation [IBA]
- innate immune response [TAS]
- mitochondrion degradation [IBA]
- negative regulation of type I interferon production [TAS]
- nucleophagy [IBA]
- post-translational protein modification [ISS]
- regulation of cilium assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TAP1
ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, DAAP-57C1.5
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
GO Process (8)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytosol to ER transport [IMP]
- intracellular transport of viral protein in host cell [IMP]
- peptide transport [IMP]
- transmembrane transport [IBA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ISG15 Connects Autophagy and IFN-?-Dependent Control of Toxoplasma gondii Infection in Human Cells.
The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-?) is the major cytokine involved in activating cell-autonomous immune responses to inhibit parasite growth within this intracellular niche. In HeLa cells, IFN-? treatment leads to ubiquitination of susceptible parasite strains, recruitment ... [more]
mBio Dec. 06, 2019; 11(5); [Pubmed: 33024031]
Throughput
- Low Throughput
Curated By
- BioGRID