BAIT
UFL1
KIAA0776, Maxer, NLBP, RCAD, RP3-393D12.1
UFM1-specific ligase 1
GO Process (6)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of protein ubiquitination [IDA]
- osteoblast differentiation [IDA]
- protein ufmylation [IDA, IMP]
- regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- response to endoplasmic reticulum stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NME2
NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF
NME/NM23 nucleoside diphosphate kinase 2
GO Process (12)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- cell adhesion [TAS]
- integrin-mediated signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleoside triphosphate biosynthetic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermis development [IMP]
- regulation of transcription, DNA-templated [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination.
p53 is the most intensively studied tumour suppressor1. The regulation of p53 homeostasis is essential for its tumour-suppressive function2,3. Although p53 is regulated by an array of post-translational modifications, both during normal homeostasis and in stress-induced responses2-4, how p53 maintains its homeostasis remains unclear. UFMylation is a recently identified ubiquitin-like modification with essential biological functions5-7. Deficiency in this modification leads ... [more]
Nat Cell Biol Dec. 01, 2019; 22(9);1056-1063 [Pubmed: 32807901]
Throughput
- High Throughput
Curated By
- BioGRID