BAIT
TWSG1
TSG, PSEC0250
twisted gastrulation BMP signaling modulator 1
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
BMP4
BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
bone morphogenetic protein 4
GO Process (100)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP]
- BMP signaling pathway involved in heart induction [IMP]
- BMP signaling pathway involved in nephric duct formation [IDA]
- BMP signaling pathway involved in renal system segmentation [ISS]
- BMP signaling pathway involved in ureter morphogenesis [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPKK activity [IDA]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IDA]
- branching involved in ureteric bud morphogenesis [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- bronchus development [IDA]
- bud dilation involved in lung branching [IDA]
- cardiac septum development [TAS]
- chondrocyte differentiation [ISS]
- common-partner SMAD protein phosphorylation [IDA]
- deltoid tuberosity development [ISS]
- endocardial cushion development [TAS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in lung morphogenesis [IDA]
- epithelial tube branching involved in lung morphogenesis [IDA]
- extracellular matrix organization [TAS]
- glomerular capillary formation [ISS]
- hematopoietic progenitor cell differentiation [IDA]
- intermediate mesodermal cell differentiation [IDA]
- kidney development [IMP]
- lung alveolus development [IDA]
- lung morphogenesis [IDA]
- lymphoid progenitor cell differentiation [IMP]
- macrophage differentiation [IDA]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesonephros development [IEP]
- metanephric collecting duct development [ISS]
- monocyte differentiation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of T cell differentiation in thymus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway [IDA]
- negative regulation of branching involved in ureteric bud morphogenesis [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell proliferation involved in heart morphogenesis [IMP]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of glomerulus development [IDA]
- negative regulation of immature T cell proliferation in thymus [IMP]
- negative regulation of mesenchymal cell proliferation involved in ureter development [IDA]
- negative regulation of metanephric S-shaped body morphogenesis [IDA]
- negative regulation of metanephric comma-shaped body morphogenesis [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis [IGI]
- osteoblast differentiation [IDA]
- positive chemotaxis [IDA]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of DNA-dependent DNA replication [IDA]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of branching involved in lung morphogenesis [ISS]
- positive regulation of cardiac muscle fiber development [IMP]
- positive regulation of cartilage development [IDA]
- positive regulation of cell death [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epidermal cell differentiation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of kidney development [IDA]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IDA]
- protein localization to nucleus [IDA]
- pulmonary artery endothelial tube morphogenesis [IDA]
- regulation of cell fate commitment [IDA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of protein import into nucleus [IDA]
- renal system development [IEP]
- secondary heart field specification [IMP]
- smooth muscle tissue development [ISS]
- smoothened signaling pathway [IEP]
- specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway [IDA]
- steroid hormone mediated signaling pathway [IMP]
- telencephalon development [IDA]
- tendon cell differentiation [ISS]
- trachea development [IDA]
- type B pancreatic cell development [IDA]
- ureter epithelial cell differentiation [ISS]
- ureter smooth muscle cell differentiation [ISS]
- ureteric bud development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.
Twisted gastrulation (TSG) is involved in specifying the dorsal-most cell fate in Drosophila embryos, but its mechanism of action is poorly understood. TSG has been proposed to modify the action of Short gastrulation (SOG), thereby increasing signalling by the bone morphogenetic protein (BMP) Decapentaplegic. SOG, an inhibitor of BMP signalling, is in turn inactivated by the protease Tolloid. Here we ... [more]
Nature Mar. 22, 2001; 410(6827);475-8 [Pubmed: 11260715]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BMP4 TWSG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.997 | BioGRID | 2235873 |
Curated By
- BioGRID