BMP1
Gene Ontology Biological Process
- cartilage condensation [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- lipoprotein metabolic process [TAS]
- multicellular organismal development [TAS]
- positive regulation of cartilage development [IDA]
- proteolysis [IDA]
- skeletal system development [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRD
Gene Ontology Biological Process
- BMP signaling pathway involved in spinal cord dorsal/ventral patterning [IMP]
- floor plate development [TAS]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of cell migration [IDA]
- negative regulation of osteoblast differentiation [IMP]
- positive regulation of cell adhesion [IDA]
- positive regulation of mesenchymal cell proliferation [IMP]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.
Twisted gastrulation (TSG) is involved in specifying the dorsal-most cell fate in Drosophila embryos, but its mechanism of action is poorly understood. TSG has been proposed to modify the action of Short gastrulation (SOG), thereby increasing signalling by the bone morphogenetic protein (BMP) Decapentaplegic. SOG, an inhibitor of BMP signalling, is in turn inactivated by the protease Tolloid. Here we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID