BAIT

MNN11

L000004260, YJL183W
Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RET2

L000004127, YFR051C
Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
GO Process (4)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

A novel mechanism for the retention of Golgi membrane proteins mediated by the Bre5p/Ubp3p deubiquitinase complex.

Wang P, Ye Z, Banfield DK

The mechanisms employed in the retention of Golgi resident membrane proteins are diverse and include features such as the composition and length of the protein's transmembrane domain and motifs that mediate direct or indirect associations with COPI-coatomer. However, in sum the current compendium of mechanisms cannot account for the localization of all Golgi membrane proteins, and this is particularly the ... [more]

Mol Biol Cell Dec. 01, 2019; 31(19);2139-2155 [Pubmed: 32673164]

Throughput

  • Low Throughput

Additional Notes

  • COPI-coatomer
  • Figure 4

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MNN11 RET2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-17.4343BioGRID
897842

Curated By

  • BioGRID