BAIT
TRPM7
ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK
transient receptor potential cation channel, subfamily M, member 7
GO Process (4)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The TRPM7 channel is inactivated by PIP(2) hydrolysis.
TRPM7 (ChaK1, TRP-PLIK, LTRPC7) is a ubiquitous, calcium-permeant ion channel that is unique in being both an ion channel and a serine/threonine kinase. The kinase domain of TRPM7 directly associates with the C2 domain of phospholipase C (PLC). Here, we show that in native cardiac cells and heterologous expression systems, G alpha q-linked receptors or tyrosine kinase receptors that activate ... [more]
Nat. Cell Biol. May. 01, 2002; 4(5);329-36 [Pubmed: 11941371]
Throughput
- Low Throughput
Curated By
- BioGRID