BAIT
FBXW7
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GO Process (24)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IDA]
- lipid homeostasis [ISS]
- negative regulation of DNA endoreduplication [IMP]
- negative regulation of Notch signaling pathway [ISS]
- negative regulation of SREBP signaling pathway [ISS]
- negative regulation of hepatocyte proliferation [ISS]
- negative regulation of triglyceride biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of epidermal growth factor-activated receptor activity [IDA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- positive regulation of proteasomal protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein stabilization [IDA]
- protein ubiquitination [IDA]
- regulation of cell cycle G1/S phase transition [TAS]
- regulation of lipid storage [ISS]
- regulation of protein localization [ISS]
- sister chromatid cohesion [IMP]
- vasculature development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOTCH1
NOTCH, TAN1
notch 1
GO Process (140)
GO Function (8)
GO Component (13)
Gene Ontology Biological Process
- Notch signaling involved in heart development [ISO, ISS]
- Notch signaling pathway [IMP, ISO]
- Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [ISO]
- aortic valve morphogenesis [ISO]
- apoptotic process involved in embryonic digit morphogenesis [ISO]
- arterial endothelial cell differentiation [ISO]
- astrocyte differentiation [IDA]
- atrioventricular node development [ISO]
- atrioventricular valve morphogenesis [ISO]
- auditory receptor cell fate commitment [ISO]
- axonogenesis [ISO]
- brain development [IEP]
- branching morphogenesis of an epithelial tube [ISO]
- cardiac atrium morphogenesis [ISO]
- cardiac chamber formation [ISO]
- cardiac epithelial to mesenchymal transition [ISO]
- cardiac left ventricle morphogenesis [ISO]
- cardiac muscle cell proliferation [ISO]
- cardiac muscle tissue morphogenesis [ISO]
- cardiac right atrium morphogenesis [ISO]
- cardiac right ventricle formation [ISO]
- cardiac septum morphogenesis [ISO]
- cardiac vascular smooth muscle cell development [ISO]
- cardiac ventricle morphogenesis [ISO]
- cell differentiation [ISO]
- cell differentiation in spinal cord [IEP]
- cell fate commitment [ISO]
- cell fate specification [ISO]
- cell migration involved in endocardial cushion formation [ISO]
- cellular response to follicle-stimulating hormone stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO, ISS]
- cilium morphogenesis [ISS]
- compartment pattern specification [ISO]
- coronary artery morphogenesis [ISO]
- coronary vein morphogenesis [ISO]
- determination of left/right symmetry [ISO]
- embryonic hindlimb morphogenesis [ISO]
- embryonic limb morphogenesis [ISO]
- endocardial cell differentiation [ISO]
- endocardial cushion morphogenesis [ISO]
- endocardium development [ISO]
- endocardium morphogenesis [ISO]
- endoderm development [ISO]
- epidermis development [ISO]
- epithelial to mesenchymal transition [ISO]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISO]
- forebrain development [ISO]
- foregut morphogenesis [ISO]
- glial cell differentiation [ISO]
- growth involved in heart morphogenesis [ISO]
- hair follicle morphogenesis [ISO]
- heart development [ISO]
- heart looping [ISO]
- heart trabecula morphogenesis [ISO]
- humoral immune response [ISO]
- in utero embryonic development [ISO]
- inflammatory response to antigenic stimulus [ISO]
- interleukin-4 secretion [ISO]
- keratinocyte differentiation [ISO]
- left/right axis specification [ISO]
- liver development [ISO]
- lung development [ISO]
- mesenchymal cell development [ISO]
- mitral valve formation [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of calcium ion-dependent exocytosis [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catalytic activity [ISO, ISS]
- negative regulation of cell death [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of endothelial cell chemotaxis [ISO, ISS]
- negative regulation of glial cell proliferation [ISO, ISS]
- negative regulation of myoblast differentiation [ISO]
- negative regulation of myotube differentiation [ISO, ISS]
- negative regulation of neurogenesis [ISO, ISS]
- negative regulation of neuron differentiation [IMP, ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of ossification [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of photoreceptor cell differentiation [ISO]
- negative regulation of pro-B cell differentiation [ISO, ISS]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube development [ISO]
- neuron differentiation [ISO]
- neuron fate commitment [ISO]
- neuronal stem cell maintenance [ISO]
- oligodendrocyte differentiation [IEP]
- organ regeneration [IEP]
- pericardium morphogenesis [ISO]
- positive regulation of BMP signaling pathway [ISO, ISS]
- positive regulation of JAK-STAT cascade [ISO, ISS]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO, ISS]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of glial cell differentiation [IMP]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO, ISS]
- positive regulation of transcription of Notch receptor target [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- prostate gland epithelium morphogenesis [ISO]
- pulmonary valve morphogenesis [ISO]
- regulation of cardioblast proliferation [IMP]
- regulation of cell migration [ISO]
- regulation of cell proliferation [IMP]
- regulation of epithelial cell proliferation [ISO]
- regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- regulation of extracellular matrix assembly [ISO]
- regulation of gene expression [ISO]
- regulation of neurogenesis [ISO]
- regulation of somitogenesis [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISO]
- response to corticosteroid [IEP]
- response to lipopolysaccharide [IEP]
- response to muramyl dipeptide [ISO]
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [ISO]
- skeletal muscle cell differentiation [ISO]
- somatic stem cell division [ISO]
- spermatogenesis [IMP]
- sprouting angiogenesis [ISO]
- tissue regeneration [IEP]
- transcription from RNA polymerase II promoter [ISO]
- tube formation [ISO, ISS]
- vasculogenesis involved in coronary vascular morphogenesis [ISO]
- venous endothelial cell differentiation [ISO]
- ventricular septum morphogenesis [ISO]
- ventricular trabecula myocardium morphogenesis [ISO]
Gene Ontology Molecular Function- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [ISO]
- core promoter binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- enzyme inhibitor activity [ISO, ISS]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin DNA binding [ISO]
- chromatin binding [ISO]
- core promoter binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- enzyme inhibitor activity [ISO, ISS]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
Tissue stem cells undergo premature senescence under stress, promoting age-related diseases; however, the associated mechanisms remain unclear. Here, we report that in response to radiation, oxidative stress, or bleomycin, the E3 ubiquitin ligase FBW7 mediates cell senescence and tissue fibrosis through telomere uncapping. FBW7 binding to telomere protection protein 1 (TPP1) facilitates TPP1 multisite polyubiquitination and accelerates degradation, triggering telomere ... [more]
Cell Metab Dec. 03, 2019; 32(5);860-877.e9 [Pubmed: 33086033]
Throughput
- Low Throughput
Curated By
- BioGRID