HDAC6
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP]
- aggresome assembly [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to topologically incorrect protein [IMP]
- histone deacetylation [IDA, ISS]
- intracellular protein transport [IMP]
- lysosome localization [IMP]
- macroautophagy [IMP]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- negative regulation of hydrogen peroxide metabolic process [IC]
- negative regulation of oxidoreductase activity [IC]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- peptidyl-lysine deacetylation [IMP]
- polyubiquitinated misfolded protein transport [IMP]
- positive regulation of chaperone-mediated protein complex assembly [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of hydrogen peroxide-mediated programmed cell death [IDA]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of signal transduction [IMP]
- protein deacetylation [IMP]
- regulation of androgen receptor signaling pathway [TAS]
- regulation of gene expression, epigenetic [IMP]
- regulation of microtubule-based movement [IC]
- regulation of receptor activity [IMP]
- response to growth factor [IMP]
- response to misfolded protein [IMP]
- response to organic substance [IMP]
- response to toxic substance [IMP]
- tubulin deacetylation [IDA, ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- aggresome [IDA]
- axon [ISS]
- caveola [IDA]
- cell leading edge [IDA]
- cytoplasm [ISS]
- cytosol [ISS]
- dendrite [ISS]
- dynein complex [IDA]
- histone deacetylase complex [IDA]
- inclusion body [IDA]
- microtubule [IDA]
- microtubule associated complex [IDA]
- nucleoplasm [IDA]
- nucleus [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [IDA]
UBE2D1
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- cellular response to hypoxia [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K48-linked ubiquitination [IDA]
- protein polyubiquitination [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1.
We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We have found that HDAC6 and Chk1 directly interact, and that HDAC6 ubiquitinates Chk1 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE2D1 HDAC6 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 338442 |
Curated By
- BioGRID