MALT1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IDA, TAS]
- activation of NF-kappaB-inducing kinase activity [IMP]
- defense response [NAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [NAS]
- nuclear export [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of protein ubiquitination [NAS]
- protein oligomerization [IDA]
- protein ubiquitination [IDA]
- proteolysis [IDA]
- regulation of apoptotic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHARPIN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-?B Activation Pathway.
The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, stimulates the canonical nuclear factor-?B (NF-?B) activation pathways through its Met1-linked linear ubiquitination activity. Here we performed cellular and mathematical modeling analyses of the LUBAC involvement in the T cell receptor (TCR)-mediated NF-?B activation pathway, using the Jurkat human T cell line. LUBAC is indispensable for TCR-induced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID