PREY

PSMD12

1500002F15Rik, AI480719, P55, RP23-319N7.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
GO Process (0)
GO Function (0)
GO Component (5)
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.

Kim J, Nakamura J, Hamada C, Taketomi T, Yano S, Okajima T, Kashiwabara SI, Baba T, Sato B, Chiba T, Tsuruta F

Precise regulation of RNA metabolism is crucial for dynamic gene expression and controlling cellular functions. In the nervous system, defects in RNA metabolism are implicated in the disturbance of brain homeostasis and development. Here, we report that deubiquitinating enzyme, ubiquitin specific peptidase 15 (USP15), deubiquitinates terminal uridylyl transferase 1 (TUT1) and changes global RNA metabolism. We found that the expression ... [more]

Mol Cell Biol Dec. 13, 2019; 40(21); [Pubmed: 32839293]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
USP15 PSMD12
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High0.5598BioGRID
3500270

Curated By

  • BioGRID