BAIT
USP15
4921514G19Rik, AI327321, E430033I05Rik, Gcap18
ubiquitin specific peptidase 15
GO Process (9)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- histone H2B conserved C-terminal lysine deubiquitination [ISO]
- monoubiquitinated protein deubiquitination [ISO]
- pathway-restricted SMAD protein phosphorylation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
PSMC5
mSUG1, RP23-418O11.3
protease (prosome, macropain) 26S subunit, ATPase 5
GO Process (4)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- cytosolic proteasome complex [ISO]
- extracellular vesicular exosome [ISO]
- holo TFIIH complex [ISA]
- inclusion body [ISO]
- membrane [ISO]
- nuclear proteasome complex [ISO]
- nucleus [ISO]
- proteasome accessory complex [IDA]
- proteasome complex [ISO]
- proteasome regulatory particle [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
Precise regulation of RNA metabolism is crucial for dynamic gene expression and controlling cellular functions. In the nervous system, defects in RNA metabolism are implicated in the disturbance of brain homeostasis and development. Here, we report that deubiquitinating enzyme, ubiquitin specific peptidase 15 (USP15), deubiquitinates terminal uridylyl transferase 1 (TUT1) and changes global RNA metabolism. We found that the expression ... [more]
Mol Cell Biol Dec. 13, 2019; 40(21); [Pubmed: 32839293]
Throughput
- High Throughput
Curated By
- BioGRID