BAIT

ARL6

BBS3, RP55

ADP-ribosylation factor-like 6

GO Process (7)

GO Function (2)

GO Component (9)

Gene Ontology Biological Process

Wnt signaling pathway [IMP]

cilium assembly [IMP, ISS]

determination of left/right symmetry [ISS]

melanosome transport [ISS]

protein localization to cilium [IMP]

protein polymerization [ISS]

protein targeting to membrane [ISS]

Gene Ontology Molecular Function

phospholipid binding [ISS]
protein binding [IPI]

Gene Ontology Cellular Component

axonemal microtubule [ISS]

cytoplasm [ISS]

extracellular vesicular exosome [IDA]

membrane coat [ISS]

primary cilium [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ARL6IP5

DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx, HSPC127

ADP-ribosylation factor-like 6 interacting protein 5

GO Process (6)

GO Function (0)

GO Component (3)

Gene Ontology Biological Process

L-glutamate transport [ISS]

intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]

negative regulation of mitochondrial membrane potential [IMP]

positive regulation of apoptotic process [IMP]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]

positive regulation of stress-activated MAPK cascade [IMP]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

extracellular vesicular exosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit.

Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP

We report here the isolation of a new member of the ADP-ribosylation factor (ARF)-like family (ARL-6) present in the J2E erythroleukemic cell line, but not its myeloid variants. Consistent with this lineage-restricted expression, ARL-6 mRNA increased with erythropoietin-induced maturation of J2E cells, and decreased with interleukin 6-induced differentiation of M1 monoblastoid cells. In tissues, ARL-6 mRNA was most abundant in ... [more]

FEBS Lett. Oct. 01, 1999; 459(1);69-74 [Pubmed: 10508919]

Throughput

Low Throughput

Curated By

BioGRID