BAIT

SHANK3

DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2

SH3 and multiple ankyrin repeat domains 3

Autism spectrum disorder (ASD) Project

GO Process (27)

GO Function (8)

GO Component (5)

Gene Ontology Biological Process

MAPK cascade [ISS]

N-methyl-D-aspartate receptor clustering [ISS]

adult behavior [IMP]

alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]

brain morphogenesis [ISS]

dendritic spine morphogenesis [ISS]

guanylate kinase-associated protein clustering [ISS]

learning [IMP, ISS]

negative regulation of actin filament bundle assembly [ISS]

negative regulation of cell volume [ISS]

positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]

positive regulation of dendritic spine development [ISS]

positive regulation of excitatory postsynaptic membrane potential [ISS]

positive regulation of glutamate receptor signaling pathway [ISS]

positive regulation of long-term neuronal synaptic plasticity [ISS]

positive regulation of synapse structural plasticity [ISS]

positive regulation of synaptic transmission, glutamatergic [ISS]

postsynaptic density assembly [ISS]

regulation of dendritic spine morphogenesis [ISS]

regulation of long term synaptic depression [ISS]

regulation of long-term synaptic potentiation [ISS]

social behavior [IMP, ISS]

striatal medium spiny neuron differentiation [ISS]

synapse assembly [ISS]

vocal learning [IMP]

vocalization behavior [IMP, ISS]

Gene Ontology Molecular Function

GKAP/Homer scaffold activity [ISS]
SH3 domain binding [ISS]
identical protein binding [ISS]
ionotropic glutamate receptor binding [ISS]
protein C-terminus binding [ISS]
protein binding [IPI]
scaffold protein binding [ISS]
zinc ion binding [ISS]

Gene Ontology Cellular Component

ciliary membrane [ISS]

neuron projection [ISS]

neuron spine [ISS]

neuronal postsynaptic density [ISS]

plasma membrane [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Homo sapiens

PREY

DLGAP1

DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP

discs, large (Drosophila) homolog-associated protein 1

GO Process (1)

GO Function (1)

GO Component (0)

Gene Ontology Biological Process

synaptic transmission [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.

Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED

We have recently isolated a novel proline-rich synapse-associated protein-1 (ProSAP1) that is highly enriched in postsynaptic density (PSD). A closely related multidomain protein, ProSAP2, shares a highly conserved PDZ (PSD-95/discs-large/ZO-1) domain (80% identity), a ppI domain that mediates the interaction with cortactin, and a C-terminal SAM (sterile alpha-motif) domain. In addition, ProSAP2 codes for five ankyrin repeats and a SH3 ... [more]

Biochem. Biophys. Res. Commun. Oct. 14, 1999; 264(1);247-52 [Pubmed: 10527873]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SHANK3 DLGAP1	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Sakai Y (2011)	High	-	BioGRID	-

Curated By

BioGRID