EIF2AK3
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [IMP]
- bone mineralization [ISS]
- calcium-mediated signaling [ISS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IMP]
- chondrocyte development [ISS]
- endocrine pancreas development [IMP]
- endoplasmic reticulum organization [ISS]
- endoplasmic reticulum unfolded protein response [IDA, TAS]
- insulin secretion [ISS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of myelination [ISS]
- negative regulation of translation [TAS]
- negative regulation of translational initiation in response to stress [TAS]
- ossification [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA, IMP]
- protein homooligomerization [IMP]
- protein phosphorylation [ISS]
- response to endoplasmic reticulum stress [IMP]
- skeletal system development [ISS]
Gene Ontology Molecular Function
HSP90B1
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- actin rod assembly [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- cellular response to ATP [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [IMP, TAS]
- protein transport [NAS]
- regulation of phosphoprotein phosphatase activity [IDA]
- response to hypoxia [IDA]
- sequestering of calcium ion [NAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum [IDA, TAS]
- endoplasmic reticulum lumen [IDA, TAS]
- endoplasmic reticulum membrane [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- midbody [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.
Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK), induces a program of translational expression in response to accumulation of malfolded protein in the endoplasmic reticulum (ER). This study addresses the mechanisms activating PEK, also designated PERK or EIF2AK3. We describe the characterization of two regions in the ER luminal portion of the transmembrane PEK that carry out ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID