BAIT
ATP2A1
ATP2A, SERCA1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
GO Process (18)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- apoptotic mitochondrial changes [IMP]
- blood coagulation [TAS]
- calcium ion import [IMP]
- calcium ion transmembrane transport [IDA]
- calcium ion transport [IDA, IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- ion transmembrane transport [TAS]
- maintenance of mitochondrion location [IMP]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP]
- negative regulation of striated muscle contraction [IMP]
- positive regulation of endoplasmic reticulum calcium ion concentration [IMP]
- positive regulation of fast-twitch skeletal muscle fiber contraction [IDA]
- positive regulation of mitochondrial calcium ion concentration [IMP]
- regulation of striated muscle contraction [IMP]
- relaxation of skeletal muscle [IDA]
- response to endoplasmic reticulum stress [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- H zone [IDA]
- I band [IDA]
- calcium channel complex [IC]
- endoplasmic reticulum membrane [IDA, TAS]
- endoplasmic reticulum-Golgi intermediate compartment [ISS]
- integral component of membrane [NAS]
- membrane [ISS]
- perinuclear region of cytoplasm [ISS]
- platelet dense tubular network membrane [TAS]
- sarcoplasmic reticulum [ISS, NAS]
- sarcoplasmic reticulum membrane [IC, TAS]
Homo sapiens
PREY
ITPR1
ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29
inositol 1,4,5-trisphosphate receptor, type 1
GO Process (19)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [ISS, TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- negative regulation of calcium-mediated signaling [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of insulin secretion [TAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to hypoxia [IDA]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 30.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID