DDB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SDS23
Gene Ontology Biological Process
- cAMP-mediated signaling [IGI]
- cellular response to glucose starvation [IMP]
- cellular response to salt stress [IMP]
- negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity [IMP]
- negative regulation of protein dephosphorylation [IDA]
- positive regulation of conjugation with cellular fusion [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- regulation of conjugation with cellular fusion [IGI]
- regulation of mitotic cell cycle [IMP]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
DDB1 was isolated as a UV-damaged DNA-binding protein, but recent studies established that it plays a role as a component of cullin 4A ubiquitin ligases. Cullin-RING complexes are the largest known ubiquitin ligase family, with hundreds of substrate-specific adaptor subunits and which are defined by characteristic motifs. A common motif for DDB1/cullin 4 ubiquitin ligases, a WDXR motif, was recently ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDB1 SDS23 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.445 | BioGRID | 784569 |
Curated By
- BioGRID