CLTA
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAB2
Gene Ontology Biological Process
- cell proliferation [TAS]
- integrin-mediated signaling pathway [IMP]
- leading edge cell differentiation [IMP]
- membrane organization [TAS]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of protein binding [IMP]
- negative regulation of protein localization to plasma membrane [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of clathrin-mediated endocytosis [IMP]
- positive regulation of early endosome to late endosome transport [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- receptor-mediated endocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Quantitative Score
- 195.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CLTA DAB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID