A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Yin L, Locovei AM, D'Urso G

In the fission yeast, Schizosaccharomyces pombe, blocks to DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the Cds1 kinase. Cds1 is required to both prevent premature entry into mitosis and to stabilize paused replication forks. Interestingly, although Cds1 is essential to maintain the viability of mutants defective in DNA replication elongation, mutants defective in ... [more]

Mol. Biol. Cell Oct. 01, 2008; 19(10);4374-82 [Pubmed: 18667534]

Throughput

Low Throughput

Ontology Terms

phenotype: heat sensitivity (APO:0000147)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC20 RAD3	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Soriano I (2021)	Low	-	PomBase	-
CDC20 RAD3	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Feng W (2001)	Low	-	BioGRID	246777

Curated By

BioGRID

Interaction Summary

CDC20

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA-directed DNA polymerase activity [IMP]

Gene Ontology Cellular Component

RAD3