BAIT
CXADR
CAR, CAR4/6, HCAR
coxsackie virus and adenovirus receptor
GO Process (17)
GO Function (8)
GO Component (19)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISS]
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cardiac muscle fiber development [ISS]
- cell-cell junction organization [ISS]
- defense response to virus [IDA]
- epithelial structure maintenance [IMP]
- gamma-delta T cell activation [ISS]
- germ cell migration [ISS]
- heart development [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- mitochondrion organization [ISS]
- neutrophil chemotaxis [IMP]
- regulation of immune response [TAS]
- transepithelial transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [ISS]
- adherens junction [IDA]
- apicolateral plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell body [ISS]
- cell junction [IDA]
- cell-cell junction [IDA]
- extracellular space [IDA]
- filopodium [ISS]
- growth cone [ISS]
- integral component of plasma membrane [NAS]
- intercalated disc [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISS]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
- tight junction [IDA]
Homo sapiens
PREY
ITGB1
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, RP11-479G22.2
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
GO Process (25)
GO Function (6)
GO Component (21)
Gene Ontology Biological Process
- B cell differentiation [IC]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-independent cell-matrix adhesion [IGI]
- cell junction assembly [TAS]
- cell migration [TAS]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cell-substrate adhesion [IMP]
- cellular defense response [TAS]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- homophilic cell adhesion via plasma membrane adhesion molecules [TAS]
- integrin-mediated signaling pathway [IMP]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- leukocyte tethering or rolling [IMP]
- mesodermal cell differentiation [IEP]
- negative regulation of anoikis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of immune response [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integrin alpha1-beta1 complex [IDA]
- integrin alpha10-beta1 complex [IDA]
- integrin alpha11-beta1 complex [IDA]
- integrin alpha2-beta1 complex [IDA]
- integrin alpha3-beta1 complex [IDA]
- integrin alpha8-beta1 complex [TAS]
- integrin complex [NAS]
- invadopodium membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- plasma membrane [IDA, NAS, TAS]
- receptor complex [IDA]
- ruffle [TAS]
- ruffle membrane [IDA, NAS]
- sarcolemma [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 25.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID