BAIT
CYP2C9
CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, RP11-208C17.6
cytochrome P450, family 2, subfamily C, polypeptide 9
GO Process (15)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular amide metabolic process [IDA]
- drug catabolic process [IMP]
- drug metabolic process [IDA, IMP]
- epoxygenase P450 pathway [IBA, TAS]
- exogenous drug catabolic process [IDA]
- monocarboxylic acid metabolic process [IDA]
- monoterpenoid metabolic process [IDA]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [IDA]
- oxidative demethylation [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IMP]
- urea metabolic process [IDA]
- xenobiotic metabolic process [IBA, TAS]
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- drug binding [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA, NAS]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IMP]
- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- drug binding [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA, NAS]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
ESYT1
FAM62A, MBC2
extended synaptotagmin-like protein 1
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 6.14 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID