BAIT
CYP2C9
CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, RP11-208C17.6
cytochrome P450, family 2, subfamily C, polypeptide 9
GO Process (15)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- arachidonic acid metabolic process [TAS]
- cellular amide metabolic process [IDA]
- drug catabolic process [IMP]
- drug metabolic process [IDA, IMP]
- epoxygenase P450 pathway [IBA, TAS]
- exogenous drug catabolic process [IDA]
- monocarboxylic acid metabolic process [IDA]
- monoterpenoid metabolic process [IDA]
- omega-hydroxylase P450 pathway [TAS]
- oxidation-reduction process [IDA]
- oxidative demethylation [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IMP]
- urea metabolic process [IDA]
- xenobiotic metabolic process [IBA, TAS]
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- drug binding [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA, NAS]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IMP]
- arachidonic acid epoxygenase activity [IBA]
- caffeine oxidase activity [IDA]
- drug binding [IDA]
- heme binding [IBA]
- monooxygenase activity [IDA, NAS]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
VEZT
VEZATIN
vezatin, adherens junctions transmembrane protein
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 100.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID