BAIT
HST4
SPAC1783.04c
Sir2 family histone deacetylase Hst4
GO Process (10)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- chromatin remodeling [ISS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at telomere [IMP]
- histone H3-K56 deacetylation [IMP]
- histone deacetylation [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of DNA repair [IMP]
- regulation of nucleosome density [IEP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
CRB2
rhp9, SPBC342.05
DNA repair protein Rad9 homolog, Rhp9
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.
The packaging of eukaryotic DNA into chromatin is likely to be crucial for the maintenance of genomic integrity. Histone acetylation and deacetylation, which alter chromatin accessibility, have been implicated in DNA damage tolerance. Here we show that Schizosaccharomyces pombe Hst4, a homolog of histone deacetylase Sir2, participates in S-phase-specific DNA damage tolerance. Hst4 was essential for the survival of cells ... [more]
Eukaryotic Cell May. 01, 2008; 7(5);800-13 [Pubmed: 18344406]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID