KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IGF1R
Gene Ontology Biological Process
- immune response [IMP]
- inactivation of MAPKK activity [IDA]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [IMP]
- phosphatidylinositol 3-kinase signaling [IC]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of JNK cascade [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Quantitative Score
- 90.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KRAS IGF1R | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2471357 |
Curated By
- BioGRID