BAIT
SYT1
P65, SVP65, SYT
synaptotagmin I
GO Process (10)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- detection of calcium ion [TAS]
- fast, calcium ion-dependent exocytosis of neurotransmitter [ISS]
- glutamate secretion [TAS]
- neurotransmitter secretion [TAS]
- positive regulation of synaptic transmission [ISS]
- protein homooligomerization [TAS]
- regulation of exocytosis [TAS]
- regulation of regulated secretory pathway [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- clathrin-sculpted acetylcholine transport vesicle membrane [TAS]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- clathrin-sculpted glutamate transport vesicle membrane [TAS]
- clathrin-sculpted monoamine transport vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- neuron projection [ISS]
- plasma membrane [TAS]
- synaptic vesicle [TAS]
Homo sapiens
PREY
CACNA1A
APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- calcium ion import [IBA]
- cell death [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.
Synaptotagmins are synaptic vesicle proteins containing two calcium-binding C2 domains which are involved in coupling calcium influx through voltage-gated channels to vesicle fusion and exocytosis of neurotransmitters. The interaction of synaptotagmins with native P/Q-type calcium channels was studied in solubilized synaptosomes from rat cerebellum. Antibodies against synaptotagmins I and II, but not IV co-immunoprecipitated [125I]omega-conotoxin MVIIC-labelled calcium channels. Direct interactions ... [more]
EMBO J. Aug. 01, 1997; 16(15);4591-6 [Pubmed: 9303303]
Throughput
- Low Throughput
Curated By
- BioGRID