KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEMA4D
Gene Ontology Biological Process
- axon guidance [TAS]
- cell adhesion [TAS]
- immune response [TAS]
- leukocyte aggregation [IMP]
- negative regulation of alkaline phosphatase activity [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- ossification involved in bone maturation [IMP]
- positive regulation of Rho GTPase activity [IMP, ISS]
- positive regulation of cell migration [IDA, ISS]
- positive regulation of collateral sprouting [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell projection organization [IMP]
- regulation of cell shape [IMP]
- regulation of dendrite morphogenesis [IMP]
- semaphorin-plexin signaling pathway [IDA, IMP]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Quantitative Score
- 60.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KRAS SEMA4D | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 4.3452 | BioGRID | 2604855 |
Curated By
- BioGRID