LIMK1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- axon guidance [TAS]
- innate immune response [TAS]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- nervous system development [TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of axon extension [ISS]
- protein phosphorylation [IDA, IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NRG1
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA, NAS]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle cell myoblast differentiation [IDA]
- cell communication [TAS]
- cell proliferation [IDA]
- cellular protein complex disassembly [IGI]
- endocardial cell differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mammary gland development [TAS]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neural crest cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of striated muscle cell differentiation [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular cardiac muscle cell differentiation [IDA]
- ventricular trabecula myocardium morphogenesis [IDA]
- wound healing [IDA, TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.
The neuregulins are receptor tyrosine kinase ligands that play a critical role in the development of the heart, nervous system, and breast. Unlike many extracellular signaling molecules, such as the neurotrophins, most neuregulins are synthesized as transmembrane proteins. To determine the functions of the highly conserved neuregulin cytoplasmic tail, a yeast two-hybrid screen was performed to identify proteins that interact ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIMK1 NRG1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| LIMK1 NRG1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID