DCR1
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA processing [IDA]
- cellular protein localization [IMP]
- chromatin silencing by small RNA [TAS]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- establishment of chromatin silencing at silent mating-type cassette [IMP]
- production of siRNA involved in RNA interference [IDA]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAL3
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IGI, IMP]
- cellular protein localization [IMP]
- dynein-driven meiotic oscillatory nuclear movement [IMP]
- gamma-tubulin complex localization [IMP]
- karyogamy [IMP]
- microtubule polymerization [IMP]
- microtubule-based movement [IMP]
- mitotic spindle stabilization [IGI]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- positive regulation of ATPase activity [IDA]
- protein localization to microtubule [IDA, IMP]
- regulation of filamentous growth [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic genetic array (SGA) analysis technique (ScSGA). The extent to which synthetic lethal or other genetic interaction networks are conserved between species remains uncertain. To address this question, we compared literature-curated and experimentally derived genetic interaction ... [more]
Quantitative Score
- -172.0 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAL3 DCR1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -5.6044 | BioGRID | 526824 | |
| DCR1 MAL3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.9017 | BioGRID | 762618 |
Curated By
- BioGRID