BAIT
CHK1
rad27, SPCC1259.13
Chk1 protein kinase
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- mitotic DNA damage checkpoint [IGI]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling [IMP]
- peptidyl-serine phosphorylation [IDA]
- signal transduction involved in DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
TLG2
SPAC823.05c
SNARE Tlg2 (predicted)
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Synthetic lethal genetic interaction networks define genes that work together to control essential functions and have been studied extensively in Saccharomyces cerevisiae using the synthetic genetic array (SGA) analysis technique (ScSGA). The extent to which synthetic lethal or other genetic interaction networks are conserved between species remains uncertain. To address this question, we compared literature-curated and experimentally derived genetic interaction ... [more]
Proc. Natl. Acad. Sci. U.S.A. Oct. 28, 2008; 105(43);16653-8 [Pubmed: 18931302]
Quantitative Score
- -140.0 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Curated By
- BioGRID