BAIT
PARD3
ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, RP11-406D17.1
par-3 family cell polarity regulator
GO Process (14)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- asymmetric cell division [TAS]
- axonogenesis [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- establishment of epithelial cell polarity [ISS]
- establishment or maintenance of cell polarity [TAS]
- myelination in peripheral nervous system [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- positive regulation of myelination [ISS]
- protein complex assembly [TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [TAS]
- protein targeting to membrane [ISS]
- tight junction assembly [ISS, TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CTNND1
CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
catenin (cadherin-associated protein), delta 1
GO Process (5)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 71.93 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID