BAIT
SLX8
SPBC3D6.11c
SUMO-targeted ubiquitin-protein ligase E3 Slx8
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RQH1
hus2, rad12, rec9, SPAC2G11.12
RecQ type DNA helicase Rqh1
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IGI]
- intra-S DNA damage checkpoint [IDA]
- maintenance of rDNA [IMP]
- mitotic DNA replication DNA duplex unwinding [ISO]
- negative regulation of mitotic recombination [IMP]
- postreplication repair [IMP]
- recombinational repair [IGI]
- regulation of mitotic recombination involved in replication fork processing [IMP]
- replication fork processing at rDNA locus [IGI]
- resolution of mitotic recombination intermediates [IMP]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
SUMO-targeted ubiquitin ligases in genome stability.
We identify the SUMO-Targeted Ubiquitin Ligase (STUbL) family of proteins and propose that STUbLs selectively ubiquitinate sumoylated proteins and proteins that contain SUMO-like domains (SLDs). STUbL recruitment to sumoylated/SLD proteins is mediated by tandem SUMO interaction motifs (SIMs) within the STUbLs N-terminus. STUbL-mediated ubiquitination maintains sumoylation pathway homeostasis by promoting target protein desumoylation and/or degradation. Thus, STUbLs establish a novel ... [more]
EMBO J. Sep. 19, 2007; 26(18);4089-101 [Pubmed: 17762865]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: heat sensitivity (APO:0000147)
Curated By
- BioGRID