A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

SUMO-targeted ubiquitin ligases in genome stability.

Prudden J, Pebernard S, Raffa G, Slavin DA, Perry JJ, Tainer JA, McGowan CH, Boddy MN

We identify the SUMO-Targeted Ubiquitin Ligase (STUbL) family of proteins and propose that STUbLs selectively ubiquitinate sumoylated proteins and proteins that contain SUMO-like domains (SLDs). STUbL recruitment to sumoylated/SLD proteins is mediated by tandem SUMO interaction motifs (SIMs) within the STUbLs N-terminus. STUbL-mediated ubiquitination maintains sumoylation pathway homeostasis by promoting target protein desumoylation and/or degradation. Thus, STUbLs establish a novel ... [more]

EMBO J. Sep. 19, 2007; 26(18);4089-101 [Pubmed: 17762865]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: heat sensitivity (APO:0000147)

Curated By

BioGRID

Interaction Summary

SLX8

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]ubiquitin protein ligase activity [IDA]

Gene Ontology Cellular Component

EME1