BAIT
RAB35
H-ray, RAB1C, RAY
RAB35, member RAS oncogene family
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IBA]
- GTP catabolic process [IDA]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [IMP]
- cellular response to nerve growth factor stimulus [ISS]
- cytokinesis [IMP]
- endocytic recycling [IBA]
- endosomal transport [IMP]
- intracellular protein transport [IBA]
- neuron projection development [ISS]
- plasma membrane to endosome transport [IMP]
- protein localization [IMP]
- protein localization to endosome [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC26A6
solute carrier family 26 (anion exchanger), member 6
GO Process (25)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [IDA]
- anion transport [IDA]
- bicarbonate transport [IDA, IMP]
- cellular response to cAMP [ISS]
- cellular response to fructose stimulus [ISS]
- cellular response to interferon-gamma [IDA]
- chloride transmembrane transport [IDA, IMP, ISS]
- chloride transport [IDA, IMP]
- epithelial fluid transport [ISS]
- formate transport [ISS]
- intestinal absorption [ISS]
- intracellular pH elevation [ISS]
- ion transport [TAS]
- mannitol transport [ISS]
- oxalate transport [IMP, ISS]
- oxalic acid secretion [ISS]
- positive regulation of dipeptide transmembrane transport [ISS]
- protein kinase C signaling [IDA]
- regulation of intracellular pH [IDA, IMP]
- sperm capacitation [ISS]
- sulfate transmembrane transport [IDA, IMP]
- sulfate transport [IMP, ISS]
- transepithelial chloride transport [IMP, ISS]
- transepithelial transport [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Nature Jun. 02, 2021; (); [Pubmed: 34079125]
Quantitative Score
- 20.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Curated By
- BioGRID