BAIT
BIN1
AMPH2, AMPHL, SH3P9
bridging integrator 1
GO Process (6)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XRCC5
AI314015, Ku80, Ku86
X-ray repair complementing defective repair in Chinese hamster cells 5
GO Process (8)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cellular hyperosmotic salinity response [ISO]
- cellular response to X-ray [ISO]
- double-strand break repair [IGI, IMP]
- double-strand break repair via nonhomologous end joining [ISO]
- hematopoietic stem cell differentiation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of neurogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
The Bin1 gene encodes a BAR adapter protein that suppresses cancer by poorly defined mechanisms. In an effort to gain insights, we identified cellular proteins that form biochemical complexes with Bin1 protein. Here we report that Bin1 physically binds to Ku, a DNA end-binding protein that functions in telomere maintenance, apoptosis, and DNA repair. Both Ku70 and Ku80 were purified ... [more]
Cell Cycle Aug. 01, 2007; 6(15);1914-8 [Pubmed: 17671430]
Throughput
- Low Throughput
Curated By
- BioGRID