RHOB
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [ISS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to ionizing radiation [IDA]
- cytokinesis [IMP]
- endosome to lysosome transport [IDA]
- negative regulation of cell cycle [ISS]
- platelet activation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transformed cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SCARB1
Gene Ontology Biological Process
- adhesion of symbiont to host [IMP]
- cholesterol efflux [ISS]
- cholesterol homeostasis [ISS]
- cholesterol import [ISS]
- detection of lipopolysaccharide [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [ISS]
- lipopolysaccharide transport [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle clearance [ISS]
- phospholipid transport [ISS]
- positive regulation of cholesterol storage [IDA]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of triglyceride biosynthetic process [ISS]
- receptor-mediated endocytosis [IDA]
- recognition of apoptotic cell [IDA]
- regulation of phagocytosis [IC]
- regulation of phosphatidylcholine catabolic process [ISS]
- reverse cholesterol transport [IEP]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
- 1-phosphatidylinositol binding [TAS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein binding [IPI]
- high-density lipoprotein particle receptor activity [IDA]
- lipopolysaccharide binding [IDA]
- lipopolysaccharide receptor activity [IDA]
- low-density lipoprotein particle binding [IDA]
- phosphatidylserine binding [ISS]
- protein binding [IPI]
- transporter activity [TAS]
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A proximity-dependent biotinylation map of a human cell.
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy1 and biochemical fractionation coupled with mass spectrometry2-4 have defined the proteomes of a variety of different organelles, but many intracellular compartments have remained refractory to such approaches. Proximity-dependent biotinylation techniques such as BioID provide an alternative approach to define the composition of ... [more]
Quantitative Score
- 80.0 [FoldChange]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINTexpress (v.3.6.1) was used to identify proximity interactions and those with a Bayesian FDR =< 0.01 were considered high confidence. The score represents the fold change of the average spectral count in sample replicates relative to the average in control replicates.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RHOB SCARB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 3334082 |
Curated By
- BioGRID