BAIT
ALP14
mtc1, SPCC895.07
TOG ortholog Alp14
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- cytoplasmic microtubule organization [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- microtubule cytoskeleton organization [IMP]
- mitotic sister chromatid segregation [IMP]
- spindle assembly involved in mitosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
KLP6
SPBC649.01c, sot2, SPBC1685.15c
kinesin-like protein Klp6
GO Process (7)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- meiotic nuclear division [IMP]
- microtubule cytoskeleton organization involved in mitosis [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic sister chromatid segregation [IMP]
- regulation of microtubule depolymerization [IMP]
- regulation of microtubule polymerization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.
Fission yeast Klp5 and Klp6 belong to the microtubule-destabilizing Kin I family. In klp5 mutants, spindle checkpoint proteins Mad2 and Bub1 are recruited to mitotic kinetochores for a prolonged duration, indicating that these kinetochores are unattached. Further analysis shows that there are kinetochores to which only Bub1, but not Mad2, localizes. These kinetochores are likely to have been captured, yet ... [more]
EMBO J. Nov. 15, 2002; 21(22);6015-24 [Pubmed: 12426374]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID