BAIT
NNF1
SPAC30.08, SPAC29E6.04
kinetochore protein Nnf1
GO Process (3)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
HOS2
hda1, phd1, SPAC3G9.07c
histone deacetylase (class I) Hos2
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- chromatin remodeling [IC]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA]
- regulation of nucleosome density [IEP]
- regulation of transcription from RNA polymerase II promoter [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.
Spindle assembly checkpoint (SAC) is an evolutionarily conserved surveillance system for chromosome missegregation. We isolated fission yeast Hos2, a component of the Dam1/DASH complex, as a multicopy suppressor of temperature-sensitive (ts) growth of nnf1-495 mutant that exhibits the minichromosome instability (mis) phenotype, producing lethal aneuploids without prominent mitotic delay. It remains elusive why SAC is satisfied in mis mutants despite ... [more]
Genes Cells Mar. 01, 2007; 12(3);311-28 [Pubmed: 17352737]
Throughput
- Low Throughput
Ontology Terms
- temperature sensitive growth (APO:0000092)
Curated By
- BioGRID