A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.

Kawashima SA, Tsukahara T, Langegger M, Hauf S, Kitajima TS, Watanabe Y

Fission yeast shugoshin Sgo1 is meiosis specific and cooperates with protein phosphatase 2A to protect centromeric cohesin at meiosis I. The other shugoshin-like protein Sgo2, which requires the heterochromatin protein Swi6/HP1 for full viability, plays a crucial role for proper chromosome segregation at both mitosis and meiosis; however, the underlying mechanisms are totally elusive. We here demonstrate that, unlike Sgo1, ... [more]

Genes Dev. Feb. 15, 2007; 21(4);420-35 [Pubmed: 17322402]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SWI6 BIR1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Choi SH (2012)	Low	-	BioGRID	636047

Curated By

BioGRID

Interaction Summary

SWI6

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [IDA]chromatin binding [IDA]methylated histone binding [IDA]nucleosomal histone binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

BIR1